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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3940 | CID5721353 | BCL6 inhibitor | Apoptosis , BCL |
CID5721353 (BCL6 inhibitor) is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical site within the BTB groove. | |||
T14561 | BI-3812 | BCL | |
BI-3812 is an inhibitor of BCL6. Which inhibiting the BTB domain of BCL6 (IC50: 3 nM). BI-3812 also has antitumor activity. | |||
T10487 | BCL6-IN-3 | BCL , Others , DNA | |
BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity. | |||
T4089 | FX1 | Apoptosis , BCL | |
FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM). | |||
T60008 | BCL6-IN-6 | BCL | |
BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressors and dose-dependently reactivates Bcl-6 target genes. | |||
T4019 | Cambinol | SIRT1/2 Inhibitor IV,NSC 112546 | Apoptosis , Phospholipase , Sirtuin |
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Ca... | |||
T8731 | BCL6-IN-7 | ||
BCL6-IN-7 is a potent BCL6 protein-protein interaction(PPI) inhibitor[1]. | |||
T14515 | BCL6-IN-8c | Others | |
BCL6-IN-8c is an orally active and potent inhibitor of B-cell lymphoma 6 (BCL6)-corepressor interaction(IC50 of 0.10 μM in cell-free enzyme-linked immunosorbent assay). | |||
T36484 | BCL6-IN-4 | BCL6-IN-4 | |
BCL6-IN-4, a potent inhibitor of B-cell lymphoma 6 (BCL6), exhibits anti-tumor activities with an inhibitory concentration 50 (IC50) value of 97 nM[1]. | |||
T75105 | OICR12694 TFA | ||
OICR12694 (JNJ-65234637) TFA, an orally active B cell lymphoma 6 (BCL6) inhibitor [1], demonstrates effectiveness in targeting BCL6 pathways. | |||
T39788 | BCL6-IN-5 | BCL6-IN-5 | |
BCL6-IN-5 is a highly effective inhibitor of BCL6. It exhibits a pIC50 value of 5.82. | |||
T78854 | WK499 | ||
BCL6-IN-10 (Compound WK499) is an inhibitor of BCL6, disrupting its interaction with the SMRT protein and promoting apoptosis, cell cycle arrest, and DNA damage. It effectively hampers the proliferation of various AML ce... | |||
T63503 | CCT369260 | ||
CCT369260 (compound 1), an orally active inhibitor targeting B-cell lymphoma 6 (BCL6), demonstrates anti-tumor efficacy with an IC50 value of 520 nM [1]. | |||
T62854 | BCL6-IN-9 | ||
BCL6-IN-9 (compound 1) is a potent inhibitor of B-cell lymphoma 6 protein (BCL6) (IC50: 3.9 nM) and can be used to study cancer. | |||
TP1797 | F1324 TFA | ||
F1324 TFA is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6), with an IC50 of 1 nM. | |||
T73333 | OICR12694 | JNJ-65234637 | |
OICR12694 (JNJ-65234637) is an orally active inhibitor of B cell lymphoma 6 (BCL6) . | |||
TP1562 | F1324 | ||
F1324 is a potent, high affinity peptidic inhibitor of B cell lymphoma 6 (BCL6) with an IC50 of 1 nM. F1324 exhibits binding t1/2 value of 441 s and has strong inhibition activity against BCL6 PPI. | |||
T78177 | CCT374705 | ||
CCT374705, an orally active BCL6 inhibitor, exhibits potent antiproliferative effects in vitro and effectively inhibits tumor growth in a lymphoma xenograft mouse model [1]. | |||
T67949 | TMX-2164 | ||
TMX-2164, a potent and irreversible inhibitor of B-cell lymphoma 6 (BCL6), demonstrates an IC50 of 152 nM, indicating strong inhibitory efficacy. It exhibits prolonged target engagement and effectively inhibits cell prol... | |||
T79801 | TCIP 1 | Epigenetic Reader Domain | |
TCIP 1 is a small molecule in the category of transcriptional/epigenetic covalent inhibitor probes (TCIPs) that forms covalent bonds with molecules targeting BCL6 and BRD4. This compound facilitates cell death gene expre... |